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- Title
Novel chimeric antigen receptors for the effective and safe treatment of NY‐BR‐1 positive breast cancer.
- Authors
Jäger, Dirk; Berger, Aileen; Tuch, Alexandra; Luckner‐Minden, Claudia; Eurich, Rosa; Hlevnjak, Mario; Schneeweiss, Andreas; Lichter, Peter; Aulmann, Sebastian; Heussel, Claus‐Peter; Fremd, Carlo; Harbottle, Richard; Zörnig, Inka; Schmidt, Patrick
- Abstract
This article discusses the development of novel chimeric antigen receptors (CARs) for the treatment of NY-BR-1 positive breast cancer. The authors conducted expression analyses to determine the frequency of NY-BR-1 expression in breast cancer and found that it is prevalent in ER+ and HER2+ disease. They also identified the binding epitopes of two novel antibodies that specifically target NY-BR-1 without cross-reactivity. In in vivo experiments, the CAR-T cells engineered with these antibodies showed reduced tumor growth and prolonged survival in mice. The authors conclude that these CAR-T cells could be suitable candidates for a Phase I clinical trial.
- Subjects
TWO-way analysis of variance; METASTATIC breast cancer; GENE expression; ONE-way analysis of variance; GENETIC engineering; LOBULAR carcinoma
- Publication
Clinical & Translational Medicine, 2024, Vol 14, Issue 7, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1776