We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Plasma extrachromosomal circular DNA as a potential diagnostic biomarker for nodular thyroid disease.
- Authors
Zhou, Meng; Lv, Wei; Han, Peng; Sun, Kai; Hao, Ziqian; Gao, Ling; Xu, Yunyun; Xu, Zhe; Shao, Shanshan; Ma, Shizhan; Guo, Qingling; Zhang, Haiqing; Liu, Ke; Yang, Fan; Yuan, Zhongshang; Wu, Guojun; Yu, Changbin; Luo, Yonglun; Yao, Zhenyu; Zhao, Jiajun
- Abstract
This article explores the potential of plasma extrachromosomal circular DNA (eccDNA) as a diagnostic biomarker for distinguishing between benign and malignant thyroid nodules, specifically papillary thyroid carcinoma (PTC). The study utilizes Circle-seq technology and machine learning to analyze eccDNA profiles in plasma samples from healthy controls, nodular thyroid goitre patients, and PTC patients. The results show significant differences in eccDNA counts and genomic characteristics between the groups, suggesting the potential of eccDNA as a non-invasive biomarker for diagnosing thyroid cancer. However, the study acknowledges the limitation of a small sample size and the need for further research to validate the findings.
- Subjects
NODULAR disease; CIRCULAR DNA; EXTRACHROMOSOMAL DNA; THYROID diseases; BIOMARKERS; CONVOLUTIONAL neural networks; CIRCULATING tumor DNA
- Publication
Clinical & Translational Medicine, 2024, Vol 14, Issue 6, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1740