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- Title
SARS‐CoV‐2 spike protein alleviates atherosclerosis by suppressing macrophage lipid uptake through regulating R‐loop formation on MSR1 mRNA.
- Authors
Zhao, Wenting; Wang, Zhen; Chen, Wenjing; Chen, Miao; Han, Jie; Yin, Xiang; Hu, Xiaotong; Wang, Shuai; Zan, Jie; Zheng, Liangrong
- Abstract
*P < .05 gl In conclusions, we for the first time demonstrate that SARS-CoV-2 S protein associates with DDX5 to decrease MSR1 expression suppressing macrophage lipid uptake to alleviate atherosclerosis. GLO:F2H7/01sep21:ctm2391-fig-0001.jpg PHOTO (COLOR): 1 SARS-CoV-2 S protein suppresses MSR1-mediated lipid uptake of macrophage through interacting DDX5. SARS-CoV-2 spike protein alleviates atherosclerosis by suppressing macrophage lipid uptake through regulating R-loop formation on MSR1 mRNA (D-E) Western blot analysis of MSR1 expression in macrophages incubated with HIS-tagged recombinant viral S1 protein (D) or S2 protein (E).
- Subjects
SARS-CoV-2; ATHEROSCLEROSIS; TAT protein; MESSENGER RNA; MACROPHAGES
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 9, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.391