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- Title
Characterization of the discriminative stimulus effects of GABA[sub A] receptor ligands in Macaca fascicularis monkeys under different ethanol training conditions.
- Authors
Grant, Kathleen A.; Waters, Courtney A.; Green-Jordan, Kristen; Azarov, Alexey; Szeliga, Kendall T.
- Abstract
Abstract Rationale: The current study was designed to extend our knowledge of the GABA[sub A] receptor system in mediating discriminative stimulus effects of ethanol in non-human primates. Objectives: To characterize the discriminative stimulus effects of ethanol, pentobarbital, midazolam, muscimol and morphine in male and female monkeys under different ethanol training conditions. Methods: Adult male (n=8) and female (n=10) Macaca fascicularis monkeys were divided into four groups and trained to discriminate 1.0 g/kg ethanol (n=8) versus water or 2.0 g/kg ethanol (n=10) versus water in a 2x2 design with training dose and sex as main group factors. Solutions were administered intragastrically (20% ethanol w/v) and responding was maintained under a fixedratio schedule of food reinforcement. Dose-response determinations of ethanol, pentobarbital, midazolam, muscimol and morphine were made under the training condition of 30 min pretreatment interval. The ethanol pretreatment interval in training sessions was then increased to 60 min and the effects of ethanol, pentobarbital and midazolam were redetermined. Results: Training dose influenced the ED50 of ethanol to produce substitution under both pretreatment intervals and pentobarbital to produce substitution under the 30-min pretreatment training interval. There were no group differences in sensitivity to midazolam. The potency of the ligands to produce ethanol substitution was consistent across groups with midazolam>pentobarbital>ethanol. There were no sex differences in substitution of the ligands for ethanol. Blood ethanol concentrations at the onset of ethanol training sessions were higher in the 2.0 g/kg groups and under longer pretreatment times,...
- Subjects
GABA receptors; PHYSIOLOGICAL effects of alcohol; PENTOBARBITAL; MIDAZOLAM; DRUG discrimination (Pharmacology)
- Publication
Psychopharmacology, 2000, Vol 152, Issue 2, p181
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s002130000510