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- Title
Fecal microbiota transplantation as an early therapeutic option in treatment refractory Clostridioides difficile infection.
- Authors
Buldukoglu, OC; Ocal, S; Cekin, AH
- Abstract
The article discusses the use of fecal microbiota transplantation (FMT) as a potential early treatment option for patients with treatment refractory Clostridioides difficile infection (CDI). The study by Koop et al. found that FMT had a treatment success rate of 76.9% in patients who did not respond to fidaxomicin treatment. The article emphasizes the importance of prompt diagnosis and treatment of CDI, particularly in patients with inflammatory bowel disease. It also highlights the potential limitations of fidaxomicin treatment, such as the development of vancomycin-resistant enterococci and the selection of resistant C. difficile strains. FMT is presented as a safe and cost-effective option for refractory cases of CDI, especially in patients with inflammatory bowel disease. The article concludes by acknowledging the contribution of the study by Koop et al. and the need for further research to expand treatment options for CDI.
- Subjects
FECAL microbiota transplantation; CLOSTRIDIOIDES difficile; CLOSTRIDIUM diseases; ENTEROCOCCAL infections; INFLAMMATORY bowel diseases; MEDICAL personnel
- Publication
Journal of Gastroenterology & Hepatology, 2024, Vol 39, Issue 6, p1200
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/jgh.16535