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- Title
A randomized controlled trial on the coloprotective effect of coenzyme Q10 on immune-inflammatory cytokines, oxidative status, antimicrobial peptides, and microRNA-146a expression in patients with mild-to-moderate ulcerative colitis.
- Authors
Farsi, Farnaz; Ebrahimi-Daryani, Nasser; Golab, Fereshteh; Akbari, Abolfazl; Janani, Leila; Karimi, Mohammad Yahya; Irandoost, Pardis; Alamdari, Naimeh Mesri; Agah, Shahram; Vafa, Mohammadreza
- Abstract
Purpose: Coenzyme Q10 (CoQ10), having potent antioxidant and anti-inflammatory pharmacological properties, has recently been shown to be a safe and promising agent in maintaining remission of ulcerative colitis (UC). This trial was, therefore, designed to determine CoQ10 efficacy on inflammation and antioxidant status, antimicrobial peptides, and microRNA-146a expression in UC patients. Methods: In this randomized double-blind controlled trial, 88 mild-to-moderate UC patients were randomly allocated to receive CoQ10 (200 mg/day) or placebo (rice flour) for 2 months. At the baseline and at an 8-week follow-up, serum levels of Nrf2, cathelicidin LL-37, β-defensin 2, IL-10, IL-17, NF-κB p65 activity in peripheral blood mononuclear cells (PBMCs), simple clinical colitis activity index questionnaire (SCCAIQ), and quality of life (IBDQ-32 score), as well as an expression rate of microRNA-146a were measured. Results: A significant reduction was detected in the serum IL-17 level, activity of NF-κB p65 in PBMCs, and also SCCAI score in the CoQ10 group compared to the placebo group, whereas IL-10 serum concentrations and IBDQ-32 score of the CoQ10 group considerably increased versus the control group; the changes of these variables were also significantly different within and between groups at the end of the study. Furthermore, CoQ10 remarkably increased serum levels of cathelicidin LL-37. A significant change in serum cathelicidin LL-37 levels was also observed between the two groups. No statistical difference, however, was seen between the two groups in terms of the serum levels of Nrf2 and β-defensin 2 and the relative expression of microRNA-146a. Conclusions: Our results indicate that CoQ10 supplementation, along with drug therapy, appears to be an efficient reducer of inflammation in patients with mild-to-moderate UC at a remission phase. Trial Registration: The research has also been registered at the Iranian Registry of Clinical Trials (IRCT): IRCT20090822002365N17.
- Subjects
THERAPEUTIC use of ubiquinones; CYTOKINES; ULCERATIVE colitis; PATIENT aftercare; COLON (Anatomy); CATHELICIDINS; MICRORNA; UBIQUINONES; OXIDATIVE stress; GENE expression; SEVERITY of illness index; TREATMENT effectiveness; RANDOMIZED controlled trials; PLACEBOS; BLIND experiment; QUESTIONNAIRES; QUALITY of life; DESCRIPTIVE statistics; MOLECULAR structure; BLOOD
- Publication
European Journal of Nutrition, 2021, Vol 60, Issue 6, p3397
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-021-02514-2