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- Title
Anthocyanins regulate serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes: a randomized controlled trial.
- Authors
Yang, Liping; Qiu, Yun; Ling, Wenhua; Liu, Zhaomin; Yang, Lili; Wang, Changyi; Peng, Xiaolin; Wang, Li; Chen, Jianying
- Abstract
Background: Epidemiological studies have suggested that adipsin and visfatin are associated with the development of type 2 diabetes. This is the first study to investigate the effects of supplementation with purified anthocyanins on serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes. Methods: A total of 160 participants with prediabetes or newly diagnosed diabetes (40–75 years old) were given 320 mg anthocyanins or placebo daily for 12 weeks in a randomized trial. Serum adipsin, serum visfatin, lipids and glycated hemoglobin A1c (HbA1c) were measured. The areas under the curve (AUCs) for glucose, insulin and C-peptide were determined before-and after-treatment by a standard 3-h 75 g oral glucose tolerance test (OGTT). Results: Relatively significant increases in serum adipsin (net change 0.15 µg/mL [0.03, 0.27], p = 0.018) and decreases in visfatin (−3.5 ng/mL [−6.69, −0.31], p = 0.032) were observed between the anthocyanins and placebo groups. We also observed significant improvements in HbA1c (−0.11% [−0.22, −0.11], p = 0.033), apolipoprotein A-1 (apo A-1) (0.12 g/L [0.03, 0.21], p = 0.012) and apolipoprotein B (apo B) (−0.07 g/L [−0.14, −0.01], p = 0.033) in response to the anthocyanins intervention. Conclusion: Purified anthocyanins supplementation for 12 weeks increased serum adipsin and decreased serum visfatin in patients with prediabetes or newly diagnosed diabetes. Trial registration ClinicalTrials.gov, identifier: NCT02689765.
- Subjects
LIPID metabolism; GLYCOSYLATED hemoglobin; NONPARAMETRIC statistics; FLAVONOIDS; HIGH performance liquid chromatography; FATTY liver; MULTIVARIATE analysis; GLYCOSIDES; PROTEOLYTIC enzymes; DIABETES; LOW density lipoproteins; MANN Whitney U Test; DIETARY supplements; RANDOMIZED controlled trials; INSULIN; PRE-tests &; post-tests; T-test (Statistics); TRANSFERASES; DESCRIPTIVE statistics; BLIND experiment; APOLIPOPROTEINS; CHI-squared test; REPEATED measures design; ANALYSIS of covariance; STATISTICAL sampling; RECEIVER operating characteristic curves; GLUCOSE; GLUCOSE tolerance tests; HIGH density lipoproteins; DATA analysis software; STATISTICAL correlation; BIOLOGICAL pigments; PREDIABETIC state; C-peptide; ALANINE aminotransferase; ASPARTATE aminotransferase; CREATININE
- Publication
European Journal of Nutrition, 2021, Vol 60, Issue 4, p1935
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-020-02379-x