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- Title
Regulation of V ibrio parahaemolyticus T3 SS2 gene expression and function of T3 SS2 effectors that modulate actin cytoskeleton.
- Authors
Kodama, Toshio; Hiyoshi, Hirotaka; Okada, Ryu; Matsuda, Shigeaki; Gotoh, Kazuyoshi; Iida, Tetsuya
- Abstract
V ibrio parahaemolyticus is a leading causative agent of seafood-borne gastroenteritis worldwide. Most clinical isolates from patients with diarrhoea possess two sets of genes for the type III secretion system ( T3 SS) on each chromosome ( T3 SS1 and T3 SS2). T3 SS is a protein secretion system that delivers effector proteins directly into eukaryotic cells. The injected effectors modify the normal cell functions by altering or disrupting the normal cell signalling pathways. Of the two sets of T3 SS genes present in V . parahaemolyticus, T3 SS2 is essential for enterotoxicity in several animal models. Recent studies have elucidated the biological activities of several T3 SS2 effectors and their roles in virulence. This review focuses on the regulation of T3 SS2 gene expression and T3 SS2 effectors that specifically target the actin cytoskeleton.
- Subjects
GENE expression; VIBRIO parahaemolyticus genetics; GENETIC regulation; BACTERIA cytoskeleton; ACTIN; GASTROENTERITIS; BACTERIA; MICROORGANISMS
- Publication
Cellular Microbiology, 2015, Vol 17, Issue 2, p183
- ISSN
1462-5814
- Publication type
Article
- DOI
10.1111/cmi.12408