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- Title
Descriptive Epidemiology of Non-syndromic Complete Atrioventricular Canal Defects.
- Authors
Agopian, A. J.; Moulik, Mousumi; Gupta-Malhotra, Monesha; Marengo, Lisa K.; Mitchell, Laura E.
- Abstract
Background: Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated non-syndromic CAVC. Risk factors for non-syndromic CAVC have not been well established. Methods: To assess the relationship between risk for non-syndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the Texas Birth Defects Registry, a large, population-based birth defects registry. Data were evaluated for 563 non-syndromic cases with CAVC. Results: Significant associations were observed between non-syndromic CAVC in offspring and maternal pregestational diabetes (adjusted prevalence ratio (aPR) 6.74; 95% confidence interval (CI) 3.67, 12.37), gestational diabetes (aPR 1.69; 95% CI 1.03, 2.79) and obesity (aPR 1.69; 95% CI 1.24, 2.30). Conclusions: Our findings add non-syndromic CAVC to the growing list of birth defects that appear to be associated with maternal diabetes and obesity.
- Subjects
REGRESSION analysis; HEART abnormalities; ENDOCARDIAL cushion defects; DISEASE prevalence; DIABETES
- Publication
Paediatric & Perinatal Epidemiology, 2012, Vol 26, Issue 6, p515
- ISSN
0269-5022
- Publication type
Article
- DOI
10.1111/ppe.12006