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- Title
Níveis séricos de cortisol basal em ratos sob tratamento oral com keir.
- Authors
de Oliveira Prado, Bárbara; Filipini, Cibelle Barcelos; da Cunha Teixeira, Ricardo Rodrigues; Melo, Diego Viana; Dias Garcia, José Antonio; Castro de Lima, Ciderléia; Dias Costa, Ana Maria Duarte; de Souza Terra, Fábio
- Abstract
The metabolism pathway of kefir remains unknown with regard to many functions due to the few studies that have addressed this issue. The purpose of the present investigation was to evaluate the effect of kefir on basal serum cortisol. For such, 60 male Wistar rats (Rattus norvegicus) weighing 180 ± 30 g were allocated to the following five groups: kefir group (KG) - 20 g/200 ml; dexamethasone group (DG) - 0.125 mg/kg; ranitidine group (RG) - 0.85 mg/kg; omeprazole group (OG) - 0.68 mg/kg; and control group (CG) - water ad libitum. Evaluations were carried out on Days 7, 14 and 21 (20 animals per evaluation). Statistical analysis involved ANOVA with the Tukey-Kramer test and Bartlett's test, with the level of significance set to 5% (p < 0.05). All analyses were performed with the aid of the BioEstat 5.0 program. At the Day 7 evaluation, a significant increase (p < 0.05) in basal cortisol was found in the RG (2.2075 ± 0.4329 µg/dL), whereas non- significant changes were found at the Day 14 evaluation. At the Day 21 evaluation, significant changes were found in the OG and RG (p < 0.01). Moreover, significant differences were found between the KG and DG (p < 0.001); mean cortisol level in the KG was 3.4 ± 0.3238 µg/dL, whereas a very low cortisol level was found in the DG (0.0275 ± 0.009574 µg/dL). Based on the present findings, kefir leads to elevated serum cortisol when consumed in continuous, daily doses. While it was not possible to establish the mechanism that contributed to this result, the increase occurred apparently without causing harm, as the animals submitted to kefir had a firm, shiny coat and appeared healthy.
- Subjects
KEFIR; PROBIOTICS; HYDROCORTISONE; RATTUS norvegicus; DEXAMETHASONE
- Publication
Revista de Ciências Farmacêuticas Básica e Aplicada, 2013, Vol 34, Issue 3, p339
- ISSN
1808-4532
- Publication type
Article