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- Title
Total Synthesis of Loroxanthin.
- Authors
Yamano, Yumiko; Tanabe, Mari; Shimada, Atsushi; Wada, Akimori
- Abstract
The first total synthesis of loroxanthin (1) was accomplished by Horner-Wadsworth-Emmons reaction of C25-apocarotenal 8 having a silyl-protected 19-hydroxy moiety with C15-phosphonate 25 bearing a silyl-protected 3-hydroxy-ε-end group. Preparation of apocarotenal 8 was achieved via Stille coupling reaction of alkenyl iodide 10 with alkenyl stananne 9, whereas phosphonate 25 was prepared through treatment of ally alcohol 23 with triethyl phosphite and ZnI2. The ally alcohol 23 was derived from the known (3R,6R)-3-hydroxy C15-aldehyde 20, which was obtained by direct optical resolution of racemate 20 using a semi-preparative chiral HPLC column.
- Subjects
HORNER-Emmons reaction; OPTICAL resolution; STILLE reaction; SONOGASHIRA reaction; MOIETIES (Chemistry); HIGH performance liquid chromatography; ALKENYL group; SILYL ethers
- Publication
Marine Drugs, 2022, Vol 20, Issue 11, p658
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md20110658