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- Title
Epigenetic regulation of satellite cell activation during muscle regeneration.
- Authors
Dilworth, F. Jeffrey; Blais, Alexandre
- Abstract
Satellite cells are a population of adult muscle stem cells that play a key role in mediating muscle regeneration. Activation of these quiescent stem cells in response to muscle injury involves modulating expression of multiple developmentally regulated genes, including mediators of the muscle-specific transcription program: Pax7, Myf5, MyoD and myogenin. Here we present evidence suggesting an essential role for the antagonistic Polycomb group and Trithorax group proteins in the epigenetic marking of muscle-specific genes to ensure proper temporal and spatial expression during muscle regeneration. The importance of Polycomb group and Trithorax group proteins in establishing chromatin structure at muscle-specific genes suggests that therapeutic modulation of their activity in satellite cells could represent a viable approach for repairing damaged muscle in muscular dystrophy.
- Subjects
EPIGENETICS; SATELLITE cells; MUSCLE regeneration; STEM cell research; POLYCOMB group protein genetics
- Publication
Stem Cell Research & Therapy, 2011, Vol 2, Issue 2, p1
- ISSN
1757-6512
- Publication type
Article
- DOI
10.1186/scrt59