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- Title
Clinical activity of pazopanib in metastatic extraosseous Ewing sarcoma.
- Authors
Attia, Steven; Okuno, Scott H.; Robinson, Steven I.; Webber, Nicholas P.; Indelicato, Daniel J.; Jones, Robin L.; Bagaria, Sanjay P.; Sherman, Courtney; Kozak, Kevin R.; Cortese, Cherise M.; McFarland, Thomas; Trent, Jonathan C.; Maki, Robert G.
- Abstract
We report a response to pazopanib in a 69-year-old man with heavily pre-treated metastatic extraosseous Ewing sarcoma in addition to molecular profiling of his tumor. To our knowledge, this case is the earliest to demonstrate activity of an oral multi-targeted kinase inhibitor in Ewing sarcoma. This case provides rationale for adding a Ewing sarcoma arm to SARC024, a phase II study of regorafenib, another multi-targeted kinase inhibitor, in patients with liposarcoma, osteosarcoma and Ewing and Ewing-like sarcomas (NCT02048371). This national multi-institutional study is ongoing.
- Subjects
BRAIN metastasis; EWING'S sarcoma; REGORAFENIB; KINASE inhibitors; TUMORS
- Publication
Rare Tumors, 2015, Vol 7, Issue 2, p86
- ISSN
2036-3605
- Publication type
Article
- DOI
10.4081/rt.2015.5992