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- Title
Antiviral and Antioxidant Properties of Echinochrome A.
- Authors
Fedoreyev, Sergey A.; Mishchenko, Natalia P.; Vasileva, Elena A.; Pislyagin, Evgeny A.; Krylova, Natalia V.; Iunikhina, Olga V.; Leonova, Galina N.; Lavrov, Vyacheslav F.; Svitich, Oksana A.; Ebralidze, Linna K.
- Abstract
The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1). The antioxidant composition, which is a mixture of echinochrome A, ascorbic acid, and α-tocopherol (5:5:1), showed higher antioxidant and antiviral effects than echinochrome A. We suppose that echinochrome A and its composition can both directly affect virus particles and indirectly enhance antioxidant defense mechanisms in the hosting cell. The obtained results allow considering the echinochrome A and the composition of antioxidants on its basis as the promising agents with the both antioxidant and antiviral activities.
- Subjects
BIOLOGICAL pigments; SEA urchins; ANTIOXIDANTS; ANTIVIRAL agents; OXIDATIVE stress; ENCEPHALITIS viruses
- Publication
Marine Drugs, 2018, Vol 16, Issue 12, p509
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md16120509