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- Title
The efficacy of amelxanox OraDisc<sup>TM</sup> on the prevention of recurrent minor aphthous ulceration.
- Authors
Murray, B.; Biagioni, P. A.; Lamey, P.‐J.
- Abstract
Background: The study was designed to determine the efficacy of OraDiscTM (active component 2 mg amlexanox) on the prevention of aphthous ulcers treated at the prodromal stage. Methods: Thermographic imaging was used to confirm the presence of a prodromal ulcer. Fifty-two patients were randomized to receive OraDiscTM ( N = 26) or vehicle patches ( N = 26). Patches were applied four times a day for 72 h over the prodromal area. The percentage of subjects who developed an ulcer at 72 h was compared between groups using the Fisher's exact test. Results: About 50% of subjects in the OraDiscTM group developed an ulcer by day 4 compared with 69% in the vehicle group. Erythema score, ulcer size, pain scores and thermographically active area and temperature all showed trends towards healing in the OraDiscTM group. Conclusion: The OraDiscTM prevents ulcers from developing when compared with the vehicle patch.
- Subjects
ULCERS; ERYTHEMA; TEMPERATURE; THERAPEUTICS; PATIENTS; CANCER pain; CUTANEOUS manifestations of general diseases; ULCER prevention; THRUSH (Mouth disease)
- Publication
Journal of Oral Pathology & Medicine, 2006, Vol 35, Issue 2, p117
- ISSN
0904-2512
- Publication type
Article
- DOI
10.1111/j.1600-0714.2006.00379.x