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- Title
Sleep Duration and Proteinuria Progression: A Population-Based Cohort Study.
- Authors
Chang, Yi-Cheng; Chang, Chia-Hsuin; Huang, Yi-Ting; Yeh, Yi-Chun; Hsieh, Meng-Lun; Yang, Wei-shun; Tu, Yu-Kang
- Abstract
<bold>Background: </bold>Extensive studies have demonstrated that sleep is an important modulator of cardiovascular and metabolic diseases. However, its impact on renal function remains uncertain.<bold>Methods: </bold>A total of 26,249 adults aged ≥20 years were recruited through voluntary health examinations in Taiwan. Sleep duration was self-reported by questionnaire. Proteinuria was graded semi-quantitatively by dipstick urine test. The associations of sleep duration with proteinuria and estimated glomerular filtration rate (eGFR) were analyzed.<bold>Results: </bold>After an average follow-up period of 2.62 years, the crude hazard ratio (HR) for proteinuria progression were 1.92 (95% CI 1.22-3.03), 1.23 (95% CI 1.09-1.39), and 1.18 (95% CI 1.00-1.39) for those with sleep duration < 4, 4-6, and > 8 h compared to those with sleep duration of 6-8 h (the reference group), respectively. The HR remained significant for those with sleep duration < 4 h (adjusted HR 1.65 [95% CI 1.05-2.61]) and 4-6 h (adjusted HR 1.19 [95% CI 1.06-1.35]) after adjustment for age, sex, blood pressure, fasting glucose, body mass index, cholesterols, triglycerides, uric acids, physical activity, smoking, alcohol consumption, income/educational levels, and baseline eGFR. However, eGFR was not significantly different among different sleep duration groups.<bold>Discussion: </bold>This result indicates short sleep duration is independently associated with the progression of proteinuria.
- Subjects
TAIWAN; SLEEP; PROTEINURIA; KIDNEY diseases; COHORT analysis; CARDIOVASCULAR diseases; METABOLIC disorders; PROTEINURIA diagnosis; GLOMERULAR filtration rate; LONGITUDINAL method; SELF-evaluation; TIME; DISEASE progression
- Publication
American Journal of Nephrology, 2019, Vol 49, Issue 1, p41
- ISSN
0250-8095
- Publication type
journal article
- DOI
10.1159/000495847