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- Title
Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B.
- Authors
Yayue Liu; Senhua Chen; Zhaoming Liu; Yongjun Lu; Guoping Xia; Hongju Liu; Lei He; Zhigang She
- Abstract
Chemical investigation of the endophytic fungus Aspergillus sp. 16-5B cultured on Czapek's medium led to the isolation of four new metabolites, aspergifuranone (1), isocoumarin derivatives (±) 2 and (±) 3, and (R)-3-demethylpurpurester A (4), together with the known purpurester B (5) and pestaphthalides A (6). Their structures were determined by analysis of 1D and 2D NMR spectroscopic data. The absolute configuration of Compound 1 was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra, and that of Compound 4 was revealed by comparing its optical rotation data and CD with those of the literature. The structure of Compound 6 was further confirmed by single-crystal X-ray diffraction experiment using CuKa radiation. All isolated compounds were evaluated for their a-glucosidase inhibitory activities, and Compound 1 showed significant inhibitory activity with IC50 value of 9.05 ± 0.60 μM. Kinetic analysis showed that Compound 1 was a noncompetitive inhibitor of a-glucosidase. Compounds 2 and 6 exhibited moderate inhibitory activities.
- Subjects
ENDOPHYTIC fungi; MICROBIAL metabolites; BIOACTIVE compounds; ASPERGILLUS; CIRCULAR dichroism
- Publication
Marine Drugs, 2015, Vol 13, Issue 5, p3091
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md13053091