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- Title
The New Antiepileptic Drugs: Clinical Applications.
- Authors
LaRoche, Suzette M.; Helmers, Sandra L.
- Abstract
In the past decade, 8 new antiepileptic drugs have been approved for use in the United States, offering many new treatment options to patients with epilepsy. With expanding use of these newer agents, primary care clinicians are challenged with understanding the roles that each new agent plays in the treatment of patients with epilepsy as well as possible interactions with other pharmacological therapies. Each new medication provides a unique profile of pharmacokinetics, adverse effects, and mechanisms of action, making an appreciation of how these agents are best utilized even more difficult. Despite well-performed trials evaluating the safety and efficacy of specific antiepileptic drugs, the lack of head-to-head comparisons among them makes it difficult to endorse a single therapeutic regimen. Limited studies have compared the new antiepileptic drugs with more traditional medications and found similar efficacy but improved tolerability of the newer agents. There remains no well-established guidelines for choosing a particular antiepileptic drug or for choosing a newer agent over a traditional one. However, careful consideration of seizure type, patient comorbidities, and specific medication toxicities aids in prescribing the most appropriate medication. This article aims to familiarize the general practitioner with the appropriate roles and effective uses of the new antiepileptic drugs in specific clinical scenarios.
- Subjects
ANTICONVULSANTS; PHARMACEUTICAL industry; CENTRAL nervous system depressants; MUSCLE relaxants; PHARMACOKINETICS; PHARMACOLOGY; CHEMICAL kinetics; PRIMARY care; THERAPEUTICS; CLINICAL medicine; PEOPLE with epilepsy
- Publication
JAMA: Journal of the American Medical Association, 2004, Vol 291, Issue 5, p615
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.291.5.615