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- Title
Breast Cancer After Hodgkin Disease: Hope for a Safer Cure.
- Authors
Yahalom, Joachim
- Abstract
Editorial. Multiple studies have documented the risk of breast cancer after Hodgkin disease (HD). The increased risk of breast cancer is associated with radiotherapy. The risk is age-related, with highest risk linked to treatment at age ten to 20 years. The median time from HD treatment to breast cancer is 15 years. Travis and colleagues provide data that allows the isolation of treatment factors and the analysis of the link between risks from radiation and chemotherapy doses. The results of Travis et al demonstrate the impact of radiation dose on risk of breast cancer. An important issue not discussed in this study is the volume of breast tissue exposed to radiation and the effect on the risk of cancer. Two thirds of women in early-stage HD do not require radiation of the axillae and protection to the upper and medial aspects of the breast could be provided by reducing the field size by using computed tomography-based planning. The Travis finding on the effect of alkylating agent-based chemotherapy might encourage interventions to reduce hormonal stimulation of breast tissue during and after treatment.
- Subjects
HODGKIN'S disease treatment; BREAST cancer risk factors; WOMEN'S health; MEDICAL radiography; DRUG therapy; CANCER treatment; THERAPEUTICS
- Publication
JAMA: Journal of the American Medical Association, 2003, Vol 290, Issue 4, p529
- ISSN
0098-7484
- Publication type
Editorial
- DOI
10.1001/jama.290.4.529