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- Title
Blood Biomarkers Relate to Cognitive Performance Years after Traumatic Brain Injury in Service Members and Veterans.
- Authors
Lippa, Sara M.; Gill, Jessica; Brickell, Tracey A.; French, Louis M.; Lange, Rael T.
- Abstract
Objective: This study examines the relationship of serum total tau, neurofilament light (NFL), ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), and glial fibrillary acidic protein (GFAP) with neurocognitive performance in service members and veterans with a history of traumatic brain injury (TBI). Method: Service members (n = 488) with a history of uncomplicated mild (n = 172), complicated mild, moderate, severe, or penetrating TBI (sTBI; n = 126), injured controls (n = 116), and non-injured controls (n = 74) prospectively enrolled from Military Treatment Facilities. Participants completed a blood draw and neuropsychological assessment a year or more post-injury. Six neuropsychological composite scores and presence/absence of mild neurocognitive disorder (MNCD) were evaluated. Within each group, stepwise hierarchical regression models were conducted. Results: Within the sTBI group, increased serum UCH-L1 was related to worse immediate memory and delayed memory (R2Δ =.065–.084, ps <.05) performance, while increased GFAP was related to worse perceptual reasoning (R2Δ =.030, p =.036). Unexpectedly, within injured controls, UCH-L1 and GFAP were inversely related to working memory (R2Δ =.052–.071, ps <.05), and NFL was related to executive functioning (R2Δ =.039, p =.021) and MNCD (Exp(B) = 1.119, p =.029). Conclusions: Results suggest GFAP and UCH-L1 could play a role in predicting poor cognitive outcome following complicated mild and more severe TBI. Further investigation of blood biomarkers and cognition is warranted.
- Subjects
NATIONAL Football League; MILITARY personnel; BRAIN injuries; GLIAL fibrillary acidic protein; SHORT-term memory; NEUROBEHAVIORAL disorders
- Publication
Journal of the International Neuropsychological Society, 2021, Vol 27, Issue 5, p508
- ISSN
1355-6177
- Publication type
Article
- DOI
10.1017/S1355617720001071