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- Title
Type I interferon licenses enhanced innate recognition and transcriptional responses to Franciscella tularensis live vaccine strain.
- Authors
Richard, Katharina; Vogel, Stefanie N.; Perkins, Darren J.
- Abstract
The innate inflammatory response to Francisella tularensis (Ft) in macrophages is significantly governed by the expression of type I interferon (IFN). Previously, the proteolytic processing and maturation of pro-IL-1β protein was shown to depend upon type I IFN expression. We show in this report that paracrine type I IFN can profoundly enhance innate recognition and TLR-dependent transcriptional responses to Ft infection upstream of its role in inflammasome regulation in both primary human monocyte-derived macrophages and primary murine peritoneal macrophages but not murine bone marrow-derived macrophages. This type I IFN-enhanced response is synergistic with TLR2 transcriptional responses, partially TLR2-independent, but strictly MyD88-dependent.
- Subjects
IMMUNE recognition; BACTERIAL vaccines; TYPE I interferons; MACROPHAGES; GRAM-negative bacteria; TOLL-like receptors; GENETIC transcription
- Publication
Innate Immunity, 2016, Vol 22, Issue 5, p363
- ISSN
1753-4259
- Publication type
Article
- DOI
10.1177/1753425916650027