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- Title
ASGPR与HBV preS1蛋白之间相互作用的验证.
- Authors
张 曦; 刘小静; 陈云茹; 孔 颖; 杨雪亮; 叶 峰; 蔺淑梅
- Abstract
Objective To verify the interaction between asialoglycoprotein receptor (ASGPR) and hepatitis B virus (HBV) preS1 protein in vivo and in vitro, and identify ASGPR as a cell-surface receptor for HBV, which could elucidate the molecular mechanism of HBV infection. Methods The preS1-ASGPR interaction was examined in mammalian two-hybrid and coimmunoprecipitation system by strictly following the manufacturers instructions. Results ASGPR interacted specifically and directly with the preS1 domain of HBV in vivo and in vitro. Conclusion ASGPR may be a candidate receptor for HBV that mediates further step of HBV entry.
- Publication
Journal of Xi'an Jiaotong University (Medical Sciences), 2016, Vol 37, Issue 2, p292
- ISSN
1671-8259
- Publication type
Article
- DOI
10.7652/jdyxb201602030