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- Title
Inhibition of β-catenin protein expression by triptolide affects self-renewal of liver cancer stem cells.
- Authors
Jian-Bo Zhou; Gang Peng; Yu-Cheng Jia; Jun Li; Jia Wang; Shu Nie; Qiu-Ying Zhang
- Abstract
The present study demonstrates the effects of triptolide, one of the constituents from Tripterygium wilfordii, on the self-renewal capacity of human hepatocellular carcinoma. The investigation revealed that triptolide markedly prevented the proliferation of liver cancer stem cells (LCSCs). For the LCSCs the minimum inhibitory concentration of triptolide was 0.6 µM. There was a significant and obvious decrease in the capacity of LCSCs to form self-sphere. Furthermore, triptolide reduced the sphere-forming capacity of LCSCs along with inhibition of β-catenin expression. However, the exposure of triptolide-treated cells to lithium chloride, an activator the Wnt/βcatenin signaling pathway, reversed the triptolide-induced inhibition of βcatenin expression and inhibited the self-renewal capacity. Therefore, triptolide effectively eradicates LCSCs through the inhibition of βcatenin protein and may act as a novel agent for the treatment of hepatocellular carcinoma.
- Subjects
CATENINS; PROTEIN expression; TRIPTOLIDE; AUTOPOIESIS; CANCER stem cells; LIVER cancer
- Publication
Bangladesh Journal of Pharmacology, 2015, Vol 10, Issue 2, p455
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v10i2.23016