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- Title
The CALM and CALM/AF10 interactor CATS is a marker for proliferation
- Authors
Archangelo, Leticia Fröhlich; Greif, Philipp A.; Hölzel, Michael; Harasim, Thomas; Kremmer, Elisabeth; Przemeck, Gerhard K.H.; Eick, Dirk; Deshpande, Aniruddha Jayant; Buske, Christian; Hrabé de Angelis, Martin; Olalla Saad, Sara Teresinha; Bohlander, Stefan K.
- Abstract
Abstract: The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.
- Subjects
CELL proliferation; CANCER cell growth; PROTEINS; CATS as laboratory animals; GENE expression; LEUKEMIA; LABORATORY mice; PREVENTION
- Publication
Molecular Oncology, 2008, Vol 2, Issue 4, p356
- ISSN
1574-7891
- Publication type
Article
- DOI
10.1016/j.molonc.2008.08.001