We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The antimicrobial activity of heyneanol A extracted from the root of taiwanese wild grape.
- Authors
S.-C. Peng; C.-Y. Cheng; F. Sheu; C.-H. Su
- Abstract
Aims: To search for antimicrobial compounds against pathogenic bacteria from grape vines ( Vitis spp.). To investigate the antimicrobial efficacy of active compounds towards methicillin-resistant Staphylococcus aureus (MRSA). Methods and Results: The root extracts of taiwanese wild grape ( Vitis thunbergii var. taiwaniana) showed marked activities against Gram-positive bacteria using the disc diffusion method. After purification, the active compound 1 was confirmed as heyneanol A by mass spectroscopy and nuclear magnetic resonance. Heyneanol A showed an minimum inhibitory concentration (MIC) value of 2 μg ml−1 towards MRSA and a value of 2 to 4 μg ml−1 for Enterococcus faecium, S. aureus, Streptococcus agalactiae and Streptococcus pyogenes. In addition, the contents of heyneanol A were determined as 36 mg g−1 in roots of taiwanese wild grape. Conclusions: The root extracts of grapevines have good antimicrobial activities towards some strains of Gram-positive pathogens. Heyneanol A, the major antimicrobial compound, is especially active towards MRSA. In addition, the abundances of heyneanol A and other stilbenes in the roots of grapevines make it possible to produce natural antimicrobial compounds from this plant species. Significance and Impact of the Study: This study reports for the first time the antimicrobial compounds in the root extracts of grapevines. The results will have clinical significance owing to their activities against MRSA.
- Subjects
ANTI-infective agents; PLANT roots; MUSCADINE grape; STAPHYLOCOCCUS aureus; METHICILLIN resistance; PATHOGENIC bacteria; GRAM-positive bacteria; MASS spectrometry; NUCLEAR magnetic resonance
- Publication
Journal of Applied Microbiology, 2008, Vol 105, Issue 2, p485
- ISSN
1364-5072
- Publication type
Article
- DOI
10.1111/j.1365-2672.2008.03766.x