We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Histamine-N-Methyl Transferase Polymorphism and Risk for Migraine.
- Authors
García-Martín, Elena; Martínez, Carmen; Serrador, Mercedes; Alonso-Navarro, Hortensia; Navacerrada, Francisco; Agúndez, José A.G.; Jiménez-Jiménez, Félix Javier
- Abstract
Background/Objectives.— Histamine has been implicated in the pathogenesis of migraine. In the CNS, histamine is almost exclusively metabolized by the polymorphic enzyme histamine N-methyltransferase (HNMT). The HNMT gene (chromosome 2q22.1), shows diverse single nucleotide polymorphisms. One of these, located in exon 4 C314T, causes the amino acid substitution Thr105Ile, related to decreased enzyme activity. The aim of this study was to investigate the possible association between HNMT polymorphism and the risk for migraine. Methods.— We studied the frequency of the HNMT genotypes and allelic variantes in 197 patients with migraine and 245 healthy controls using a PCR-RLFP method. Results.— The frequencies of the HNMT genotypes and allelic variants did not differ significantly between migraine patients and controls, and were unrelated with the age of onset of migraine attacks, gender, personal history of allergic diseases, family history of migraine, or presence of aura. Conclusion.— The results of the present study suggest that HNMT polymorphism in not related with the risk for migraine.
- Subjects
HEADACHE; MIGRAINE; HEAD diseases; CLUSTER headache; HISTAMINERGIC mechanisms; HISTAMINE; BIOGENIC amines; GENETIC polymorphism research; GENETICS
- Publication
Headache: The Journal of Head & Face Pain, 2008, Vol 48, Issue 9, p1343
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/j.1526-4610.2007.01056.x