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- Title
Immunologic response to fungus is not universally associated with chronic rhinosinusitis
- Authors
Ponikau, Jens U.; Sherris, David A.; Kern, Eugene B.
- Abstract
Abstract: In the December 2009 issue of this journal, Orlandi et al presented a study in which peripheral blood mononuclear cells (PBMCs) from chronic rhinosinusitis (CRS) patients (5 from Texas, 5 from Utah) and seven nonhealthy controls were stimulated with fungal extracts. Despite the small numbers, they confirmed important aspects of previous studies: 1) CRS patients'' PBMCs react to certain fungal stimuli by producing significantly (P < 0.05) higher amounts of interleukin (IL)-5 and IL-13 when compared to controls; 2) CRS patients have an enhanced humoral response (significantly elevated immunoglobulin [Ig] G levels to Alternaria); and 3) CRS patients react independently from an IgE-mediated allergy, as evidenced by that fact that nonallergic CRS patients also produced IL-5 in response to fungal stimuli. Unfortunately, the authors chose not to highlight their positive results. They emphasized what they failed to demonstrate, specifically an immune response to fungi above a certain threshold in some patients (Utah) with milder CRS. However, these results are potentially explained by the different methods used, and care should be applied when interpreting their results.
- Subjects
IMMUNE response; SINUSITIS; INTERLEUKINS; FUNGAL reproduction; IMMUNOGLOBULINS; ALTERNARIA; ALLERGIES; PATIENTS
- Publication
Otolaryngology-Head & Neck Surgery, 2010, Vol 143, Issue 5, p607
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1016/j.otohns.2010.07.001