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- Title
Analysis of the Kit and Pdgfra genes in the patch-extended (Phe) mutation.
- Authors
STEPHENSON, DENNIS A.; NOVAK, EDWARD K.; CHAPMAN, VERNE M.
- Abstract
The patch (Ph) locus allele, patch-extended (Phe), has significantly less pigmentation than the original mutation and homozygotes have been known to survive to term. Analysing inter- subspecific F1 hybrids, we were able to demonstrate that Phe is a deletional mutation encompassing the platelet-derived growth factor receptor alpha subunit (Pdgfra). The deletion does not appear to extend into the coding sequence of the Kit gene (a related tyrosine kinase receptor). However, we were able to demonstrate that, while the Kit gene is transcribed, it does not encode a functionally active receptor.
- Publication
Genetics Research, 1998, Vol 72, Issue 3, p205
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/s0016672398003425