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- Title
New Perspectives for the Rescue of Cognitive Disability in Down Syndrome.
- Authors
Bartesaghi, Renata; Haydar, Tarik F.; Delabar, Jean Maurice; Dierssen, Mara; Martínez-Cué, Carmen; Bianchi, Diana W.
- Abstract
Down syndrome (DS) is a relatively common genetic condition caused by the triplication of human chromosome 21. No therapies currently exist for the rescue of neurocognitive impairment in DS. This review presents exciting findings showing that it is possible to restore brain development and cognitive performance in mouse models of DS with therapies that can also apply to humans. This knowledge provides a potential breakthrough for the prevention of intellectual disability in DS.
- Subjects
DIAGNOSIS of Down syndrome; HUMAN chromosome abnormalities; INTELLECTUAL disabilities; BRAIN abnormalities; PREVENTIVE medicine; MICE behavior; LABORATORY mice
- Publication
Journal of Neuroscience, 2015, Vol 35, Issue 41, p13843
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.2775-15.2015