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- Title
Simultaneous Quantification of Metolazone and Ramiprilin Their Combined Dosage Form by First Order Derivative Spectroscopic Method.
- Authors
MODI, Pratik R.; CHHALOTIYA, Usmangani K.; SHAH, Dimal A.; MEHTA, Falgun A.; BHATT, Kashyap K.
- Abstract
A simple, accurate and precise first order derivative spectrophotometric method was developed for simultaneous determination of Metolazone (MET) and Ramipril (RAM) in their combined pharmaceutical dosage fonn. MET and RAM were quantified using first derivative responses at 285nm and 212nm respectively. Methanol was taken as a common solvent. The calibration curve were linear in the concentration range of 5-25 μg/mL for MET and 8-24 μg/mL for RAM. The method was validated and found to be accurate and precise. Developed method was successfully applied for the estimation of MET and RAM in their combined dosage form.
- Subjects
METOLAZONE; DRUG dosage; SPECTRUM analysis; CHEMICAL derivatives; RAMIPRIL
- Publication
Turkish Journal of Pharmaceutical Sciences, 2015, Vol 12, Issue 2, p169
- ISSN
1304-530X
- Publication type
Article