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- Title
GLUCOSE METABOLISM OF THE ISOLATED ECCRINE SWEAT GLAND. I. The Effects of Mecholyl, Epinephrine and Ouabain.
- Authors
Sato, Kenzo; Dobson, Richard L.
- Abstract
The effects of mecholyl, epinephrine and ouabain on glucose metabolism were studied in freshly dissected human and monkey paw eccrine sweat glands. Both showed active glycolytic activity which was further stimulated by mecholyl and epinephrine. Ouabain inhibited unstimulated as well as mecholyl or epinephrine-stimulated glycolysis and mecholyl-stimulated 14CO2 production. Anaerobic incubation and the addition of KCN markedly enhanced lactate production Mecholyl and lower concentrations of epinephrine stimulated both 14CO2 and lactate production. Higher concentrations of epinephrine stimulated lactate production but markedly suppressed 14CO2 production. A possible link between energy production and glandular secretion was discussed.
- Subjects
SWEAT glands; GLUCOSE; CUTANEOUS glands; ADRENALINE; BRONCHODILATOR agents; MONKEYS
- Publication
Journal of Investigative Dermatology, 1971, Vol 56, Issue 4, p272
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12261004