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- Title
RUNX1 mutations are rare in chronic phase polycythaemia vera.
- Authors
Butcher, Carolyn M.; Neufing, Petra J.; Eriksson, Lena; Carmichael, Catherine L.; Wilkins, Ella J.; Melo, Junia V.; Lewis, Ian D.; Bardy, Peter G.; Scott, Hamish S.; D'Andrea, Richard J.
- Abstract
The article presents a study which investigates the possible initiating event of activity disruption in patients with chronic myeloproliferative neoplasms (MPN). The study performs a comprehensive mutational screen of RUNXI exons using High Resolution Melt analysis, Polymerase chain reaction (PCR) amplification and sequencing of samples to detect RUNX1 mutations. Result shows that RUNX1 may contribute to the two disease entities of MPN and acute leukemia.
- Subjects
GENETIC transcription; MYELOPROLIFERATIVE neoplasms; GENETIC mutation; EXONS (Genetics); POLYMERASE chain reaction; ACUTE leukemia; PATIENTS
- Publication
British Journal of Haematology, 2011, Vol 153, Issue 5, p672
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2011.08589.x