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- Title
Boosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca<sup>2+</sup> overload and obatoclax-mediated autophagy inhibition as supported by a novel nano-modulator GO-Alg@CaP/CO.
- Authors
Wang, Xuan; Li, Yunhao; Jia, Fan; Cui, Xinyue; Pan, Zian; Wu, Yan
- Abstract
Background: By hindering energy supply pathway for cancer cells, an alternative therapeutic strategy modality is put forward: tumor starvation therapy. And yet only in this blockade of glucose supply which is far from enough to result in sheer apoptosis of cancer cells. Results: In an effort to boost nutrient starvation-dominated cancer therapy, here a novel mitochondrial Ca2+ modulator Alg@CaP were tailor-made for the immobilization of Glucose oxidase for depriving the intra-tumoral glucose, followed by the loading of Curcumin to augment mitochondrial Ca2+ overload to maximize the therapeutic efficiency of cancer starvation therapy via mitochondrial dysfunctions. Also, autophagy inhibitors Obatoclax were synchronously incorporated in this nano-modulator to highlight autophagy inhibition. Conclusion: Here, a promising complementary modality for the trebling additive efficacy of starvation therapy was described for cutting off the existing energy sources in starvation therapy through Curcumin-augmented mitochondrial Ca2+ overload and Obatoclax-mediated autophagy inhibition.
- Subjects
MITOCHONDRIA; AUTOPHAGY; CANCER treatment; GLUCOSE oxidase; POWER resources; CANCER cells; CURCUMIN
- Publication
Journal of Nanobiotechnology, 2022, Vol 20, Issue 1, p1
- ISSN
1477-3155
- Publication type
Article
- DOI
10.1186/s12951-022-01439-0