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- Title
Induction of CD94/NKG2A expression on T cells in mixed lymphocyte culture by CD14<sup>+</sup> cells from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells.
- Authors
Tanaka, Junji; Tutumi, Yutaka; Li, Zhang; Katho, Naoko; Sugita, Junichi; Mori, Akio; Toyoshima, Nobuyasu; Ota, Shuichi; Kobayashi, Masanobu; Kasai, Masaharu; Asaka, Masahiro; Imamura, Masahiro
- Abstract
Summary. We report the increased expression of inhibitory natural killer (NK) cell receptor, CD94/NKG2A, for human leucocyte antigen (HLA) class I on CD8+ T cells in granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells (G-PBMC) after mixed lymphocyte culture (MLC). The addition of purified CD14+ cells to CD14-depleted G-PBMC-induced CD94/NKG2A expression in a dose-dependent fashion; however, this enhancing effect was inhibited by the membrane between responder cells and CD14+ cells. Therefore, CD14+ cells in G-PBMC induce CD94/NKG2A expression on CD8+ T cells, which in turn appear to downregulate alloresponses after allogeneic peripheral blood stem cell transplantation.
- Subjects
GRAFT versus host disease; STEM cell transplantation; CD4 antigen; KILLER cells
- Publication
British Journal of Haematology, 2002, Vol 117, Issue 3, p751
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2002.03525.x