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- Title
Unsaturated iron binding capacity and transferrin saturation are equally reliable in detection of HFE hemochromatosis
- Authors
Murtagh, Luke J.; Whiley, Michael; Wilson, Susan; Tran, Huy; Bassett, Mark L.
- Abstract
OBJECTIVE:Unsaturated iron binding capacity (UIBC) has been proposed as an inexpensive alternative to transferrin saturation for detection of hereditary hemochromatosis. The aim of this study was to compare, in a hospital referral clinic, the reliability of transferrin saturation and UIBC for detection of subjects who have inherited HFE (HLA-asociated iron overload) genotypes predisposing to iron overload.METHODS:Serum transferrin saturation, UIBC, and ferritin were tested in 110 consecutive subjects. Optimum thresholds were determined from receiver operating characteristic curves.RESULTS:Of 110 subjects, 44 carried significant HFE mutations (C282Y/C282Y or C282Y/H63D). In genetically predisposed subjects with biochemical expression, the optimum threshold for transferrin saturation was 43%, giving a sensitivity of 0.88 and specificity 0.95. For UIBC, the optimum threshold was 143 μg/dL (25.6 μmol/L), giving a sensitivity of 0.91 and specificity of 0.95. In patients referred with a family history or clinical suspicion of hemochromatosis, transferrin saturation and UIBC were highly reliable predictors of genotype. In patients referred for investigation of abnormal liver enzymes without a known family history of hemochromatosis, a normal transferrin saturation or normal UIBC was highly reliable in excluding hemochromatosis.CONCLUSIONS:Transferrin saturation and UIBC have equal reliability in ability to predict hemochromatosis. UIBC should be considered as an alternative to transferrin saturation in detection of hemochromatosis.
- Subjects
HEMOCHROMATOSIS diagnosis; TRANSFERRIN; GENETIC mutation
- Publication
American Journal of Gastroenterology (Springer Nature), 2002, Vol 97, Issue 8, p2093
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.2002.05927.x