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- Title
Diastereodivergent Henry Reaction for the Stereoselective Construction of Nitrogen-Containing Tetrasubstituted Carbons: Application to Total Synthesis of Manzacidins A and C.
- Authors
Kudoh, Takayuki; Araki, Yuya; Miyoshi, Natsumi; Tanioka, Mizuho; Sakakura, Akira
- Abstract
β,β-Disubstituted β-amino alcohols has been synthesized in a diastereodivergent manner from chiral secondary nitroalkanes as starting materials. In this key Henry reaction, the use of different protecting groups resulted in the diastereoselective construction of the tetrasubstituted carbon stereocenter with different configuration. Based on this methodology, a total synthesis of manzacidins A and C has been achieved.
- Subjects
AMINO alcohol synthesis; NITROALDOL reactions; NITROALKANES
- Publication
Asian Journal of Organic Chemistry, 2017, Vol 6, Issue 12, p1760
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.201700568