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- Title
Structure and function of bacterial H-NS protein.
- Authors
Grainger, David C.
- Abstract
The histone-like nucleoid structuring (H-NS) protein is a major component of the folded chromosome in Escherichia coli and related bacteria. Functions attributed to H-NS include management of genome evolution, DNA condensation, and transcription. The wide-ranging influence of H-NS is remarkable given the simplicity of the protein, a small peptide, possessing rudimentary determinants for self-association, hetero-oligomerisation and DNA binding. In this review, I will discuss our understanding of H-NS with a focus on these structural elements. In particular, I will consider how these interaction surfaces allow H-NS to exert its different effects.
- Subjects
H-NS protein; BACTERIAL protein structure; BACTERIAL protein genetics; DNA condensation; ESCHERICHIA coli proteins; OLIGOMERIZATION
- Publication
Biochemical Society Transactions, 2016, Vol 44, Issue 6, p1561
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20160190