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- Title
A review of the mesotheliogenic potency of cleavage fragments found in talc.
- Authors
Miller, E; Beckett, EM; Cheatham, D; Comerford, CE; Lewis, RC; Krevanko, C; Mandava, N; Pierce, JS
- Abstract
It has long been recognized that amphibole minerals, such as cleavage fragments of tremolite and anthophyllite, may exist in some talc deposits. We reviewed the current state of the science regarding the factors influencing mesotheliogenic potency of cleavage fragments, with emphasis on those that may co-occur in talc deposits, including dimensional and structural characteristics, animal toxicology, and the most well-studied cohort exposed to talc-associated cleavage fragments. Based on our review, multiple lines of scientific evidence demonstrate that inhaled cleavage fragments associated with talc do not pose a mesothelioma hazard.
- Subjects
TALC; AMPHIBOLES; MESOTHELIOMA; MINERALS; TOXICOLOGY
- Publication
Toxicology & Industrial Health, 2024, Vol 40, Issue 7, p398
- ISSN
0748-2337
- Publication type
Article
- DOI
10.1177/07482337241246924