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- Title
Antioxidant and Antiadipogenic Activities of Galkeun-Tang, a Traditional Korean Herbal Formula.
- Authors
Soo-Jin Jeong; Sae-Rom Yoo; Ohn-Soon Kim; Chang-Seob Seo; Hyeun-Kyoo Shin
- Abstract
Galkeun-tang (GKT; Galgen-tang in Chinese and Kakkon-to in Japanese), a traditional herbal formula, has been used for treatment of the common cold. Here, we report in vitro antioxidant and antiadipogenic effects of GKT. GKT increased the activities of scavenging 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. GKT also significantly reduced the malondialdehyde (MDA) generation during low-density lipoprotein (LDL) oxidation and the electrophoretic mobility of oxidized LDL, indicating inhibitory effects of GKT on Cu2+-mediated oxidation of LDL. Regarding antiadipogenic activity, GKT treatment significantly suppressed lipid accumulation, triglyceride production, and glycerol-3- phosphate dehydrogenase (GPDH) activity in differentiated 3T3-L1 adipocytes. Consistent with this, GKT significantly reduced the secretion of leptin, a major adipokine, in differentiated 3T3-L1 adipocytes. Overall, our findings suggest that GKT has the potential for antioxidative and antiadipogenic properties.
- Subjects
BOTANIC medicine; ANALYSIS of triglycerides; IN vitro studies; RESEARCH funding; DATA analysis; HERBAL medicine; AGAR; IMMUNODIAGNOSIS; DESCRIPTIVE statistics; LOW density lipoproteins; ANTIOXIDANTS; ASIAN medicine; ONE-way analysis of variance; STATISTICS; CELL differentiation; STAINS &; staining (Microscopy); BIOLOGICAL assay; ELECTROPHORESIS; CULTURES (Biology); CELL surface antigens; CHROMATOGRAPHIC analysis
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2014, Vol 2014, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2014/763494