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- Title
Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans.
- Authors
Zhimin Yan; Hong Hua; Yanying Xu; Samaranayake, Lakshman P.
- Abstract
This study was designed to evaluate the in vitro antifungal activities of four traditional Chinese medicine (TC M) extracts. The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays. They were tested against six oral Candida species, Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis, and Candida guilliermondii, including clinical isolates from HIV-negative, HIV-positive, and Sj"ogren,s syndrome patients. It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all six Candida spp, and to isolates from HIV-negative, HIV-positive, and Sj"ogren,s syndrome patients. The MIC values ranged from 16 to 128 лg/mL. More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed. We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis.
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2012, Vol 2012, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2012/106583