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- Title
Acute phase characteristics and long-term complications of pulmonary embolism in COVID-19 compared to non-COVID-19 cohort: a large single-centre study.
- Authors
Franco-Moreno, A.; Brown-Lavalle, D.; Campos-Arenas, M.; Rodríguez-Ramírez, N.; Muñoz-Roldán, C.; Rubio-Aguilera, A. I.; Muñoz-Rivas, N.; de Girón, J. Bascuñana-Morejón; Fernández-Vidal, E.; Palma-Huerta, E.; Estévez-Alonso, S.; Rodríguez-Gómez, B.; Manzano-Valera, S.; Pedrero-Tomé, R.; Casado-Suela, M.; Bibiano-Guillén, C.; Mir-Montero, M.; Torres-Macho, J.; Bustamante-Fermosel, A.; the Infanta Leonor Thrombosis Research Group
- Abstract
Background: To compare the severity of pulmonary embolism (PE) and the long-term complications between patients with and without COVID-19, and to investigate whether the tools for risk stratification of death are valid in this population. Methods: We retrospectively included hospitalized patients with PE from 1 January 2016 to 31 December 2022. Comparisons for acute episode characteristics, risk stratification of the PE, outcomes, and long-term complications were made between COVID and non-COVID patients. Results: We analyzed 116 (27.5%) COVID patients and 305 (72.4%) non-COVID patients. In patients with COVID-19, the traditional risk factors for PE were absent, and the incidence of deep vein thrombosis was lower. COVID patients showed significantly higher lymphocyte count, lactate dehydrogenase, lactic acid, and D-dimer levels. COVID patients had PE of smaller size (12.3% vs. 25.5% main pulmonary artery, 29.8% vs. 37.1% lobar, 44.7% vs. 29.5% segmental and 13.2% vs. 7.9% subsegmental, respectively; p < 0.001), less right ventricular dysfunction (7.7% vs. 17.7%; p = 0.007) and higher sPESI score (1.66 vs. 1.11; p < 0.001). The need for mechanical ventilation was significantly higher in COVID patients (8.6% vs. 1.3%; p < 0.001); However, the in-hospital death was less (5.2% vs. 10.8%; p = 0.074). The incidence of long-term complications was lower in COVID cohort (p < 0.001). PE severity assessed by high sPESI and intermediate and high-risk categories were independently associated with in-hospital mortality in COVID patients. Conclusion: The risk of in-hospital mortality and the incidence of long-term complications were lower in COVID-19. The usual tools for risk stratification of PE are valid in COVID patients.
- Subjects
PULMONARY embolism; COVID-19; RIGHT ventricular dysfunction; VENOUS thrombosis; LACTATE dehydrogenase; ARTIFICIAL respiration; LYMPHOCYTE count
- Publication
BMC Pulmonary Medicine, 2023, Vol 23, Issue 1, p1
- ISSN
1471-2466
- Publication type
Article
- DOI
10.1186/s12890-023-02323-9