We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and cyclization reactions of 2-(6-methylquinolin-4-yl)malononitriles and ethyl 2-cyano-2-(6-methylquinolin-4-yl)acetates.
- Authors
Ismail, Mostafa M.
- Abstract
The nucleophilic substitution reactions of 2,4-dichloro-6-methylquinoline (1) and 4-chloro-6-methylquinolin-2(1H)-one (7) with malononitrile and ethyl cyanoacetate are described. The quinolinylmalononitrile 8a and cyanoacetate 8b were utilized to prepare the novel polyfunctionalized benzoquinolinones 10a,b, pyridylquinolinones 11a,b, pyrazolylquinolinones 12a-e, isoxazolylquinolinone 13, pyrimidylquinolinones 14a-c, thienoquinolinones 15, 16a,b, and pyridothienoquinolinones 17a,b. The structures of the new compounds were based on analytical and spectral results.
- Subjects
CHEMICAL reactions; BIOSYNTHESIS; QUINOLINE; METHYLTRANSFERASES; ETHYL chloride; BENZOATES
- Publication
Journal of the Serbian Chemical Society, 2006, Vol 71, Issue 7, p721
- ISSN
0352-5139
- Publication type
Article
- DOI
10.2298/JSC0607721I