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- Title
Membrane Depolarization Sensitizes Pseudomonas aeruginosa Against Tannic Acid.
- Authors
Aashique, Md.; Roy, Amrita; Kosuru, Rekha Yamini; Bera, Soumen
- Abstract
The use of dietary polyphenols as antimicrobial agents has gained immense popularity in recent years, although few of them—like tannic acid has limited use in this field of research; one of the main reasons is its restricted access through the bacterial membrane. Dissipating the bacterial membrane potential with a sub-lethal dosage of the protonophore, carbonyl cyanide m-chlorophenyl hydrazone, enhanced the tannic acid-cytotoxicity with subsequent inhibition of aerobic respiration in Pseudomonas aeruginosa strains which otherwise exhibited a minimum response to tannic acid. However, ascorbic acid, an antioxidant and bacterial membrane-stabilizing compound, had rescued the cells from both tannic acid- and CCCP-mediated lethality. The results suggested that dispersing the membrane potential with a protonophore can enhance the antibacterial properties of tannic acid.
- Subjects
PSEUDOMONAS aeruginosa; BACTERIAL cell walls; MEMBRANE potential; VITAMIN C; CYANIDES; TANNINS; POLYPHENOLS
- Publication
Current Microbiology, 2021, Vol 78, Issue 2, p713
- ISSN
0343-8651
- Publication type
Article
- DOI
10.1007/s00284-020-02330-7