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- Title
Ciprofloxacin Penetration into the Pulmonary Parenchyma in Japanese Patients.
- Authors
Shuji Haraguchi; Masafumi Hioki; Koji Yamashita; Koan Orii; Yasuo Yamashita; Jun Kawamura; Mina Takushima; Naoya Endo; Kiyoshi Koizumi; Kazuo Shimizu
- Abstract
AbstractPurpose  To assess the degree of penetration of intravenous (i.v.) ciprofloxacin into the lung parenchyma resected for lung carcinoma in Japanese patients.Methods  Ciprofloxacin was given i.v. over 1âh to ten Japanese patients with non-small cell lung carcinoma. We took 1âg of normal lung parenchyma and 1âml of blood serum for analysis when the lung was resected. Ciprofloxacin concentrations were determined by high-performance liquid chromatography.Results  The mean time from the end of ciprofloxacin administration to lung resection was 135 55âmin (range, 75â223âmin). The mean concentrations of ciprofloxacin in the lung parenchyma and blood serum were 4.9 2.0âg/g (range, 2.1â7.9) and 1.5 0.7âg/ml (range, 0.8â2.7). The mean tissue per serum concentration ratio was 3.6 2.2 (range, 1.9â8.7).Conclusion  The concentrations of ciprofloxacin in the lung parenchyma after i.v. administration in Japanese patients were above the minimal inhibitory concentration for bacteria from at least 75âmin until 4âh later.
- Subjects
CIPROFLOXACIN; LUNG cancer; LIQUID chromatography; SURGICAL excision; BLOOD plasma; SERUM; BACTERIA
- Publication
Surgery Today, 2007, Vol 37, Issue 4, p282
- ISSN
0941-1291
- Publication type
Article
- DOI
10.1007/s00595-006-3393-4