We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Morphology and fluorescein leakage in diabetic retinal microaneurysms: a study using multiple en face OCT angiography image averaging.
- Authors
Fukuda, Yosuke; Nakao, Shintaro; Kaizu, Yoshihiro; Arima, Mitsuru; Shimokawa, Sakurako; Wada, Iori; Yamaguchi, Muneo; Takeda, Atsunobu; Sonoda, Koh-Hei
- Abstract
Purpose: To investigate the relevance of microaneurysm morphology in optical coherence tomography angiography (OCTA) image averaging and fluorescein leakage in diabetic retinopathy (DR). Methods: In 38 consecutive patients with DR, ten consecutive 3- × 3-mm fovea-centered OCTA (HS100, Canon Inc., Tokyo, Japan) and fluorescein angiography (FA) were performed, and averaged OCTA images were created based on the 10 images. After detecting all microaneurysms in FA images, the morphology was classified into four types (focal bulge, saccular/pedunculated, fusiform, and mixed) using averaged OCTA images. The correlation between microaneurysm leakage in FA, retinopathy stage, and microaneurysm morphology was estimated. Results: Thirty-eight eyes (50.0%) of the 33 patients were available for analysis, and 370 (63.5%) of the 583 FA-detected microaneurysms were morphologically classifiable (focal bulge, 46; saccular/pedunculated, 143; fusiform, 29; and mixed, 152) in OCTA. There was a significant correlation between stage and percentage of microaneurysm morphology and between morphology and the presence of leakage (P < 0.0001 and P < 0.01, respectively). The proportion of focal bulges decreased with stage progression, while the other three types increased with stage progression. The percentage of FA leakage for focal bulge, saccular/pedunculated, fusiform, and mixed was 41.3%, 66.4%, 82.8%, and 66.4%, respectively, and the fusiform type showed significant FA leakage. Conclusion: Microaneurysm morphology is correlated with the DR stage and FA leakage. Microaneurysm morphology recognition using OCTA image averaging may be useful for the clinical evaluation of DR.
- Subjects
CANON Inc.; OPTICAL coherence tomography; FLUORESCENCE angiography; FLUORESCEIN; LEAKAGE; DIABETIC retinopathy
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2022, Vol 260, Issue 11, p3517
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-022-05713-7