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- Title
Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum.
- Authors
Kumar, Sanjai; Miller, Louis H.; Quakyi, Isabella A.; Keister, David B.; Houghten, Richard A.; Maloy, W. Lee; Moss, Bernard; Berzofsky, Jay A.; Good, Michael F.
- Abstract
Malaria is initiated by the inoculation of a susceptible host with sporozoites from an infected mosquito. The sporozoites enter hepatocytes and develop for a period as exoerythrocyte or hepatic stage parasites1. Vaccination with irradiated sporozoites can provide protective immunity1 and a recent study2 shows that this can also be conferred by immunization with a recombinant salmonella expressing only the circumsporozoite protein that normally covers the sporozoites. Protection against infection is likely to be mediated by cytotoxic CD8+ cells, as depletion of CD8+ T cells in a sporozoite-immunized animal can completely abrogate immunity3,4. Here we demonstrate directly the existence of CD8+ cytotoxic T lymphocytes (CTL) that recognize the circumsporozoite protein. B10.BR mice immunized with sporozoites or with recombinant vaccinia virus expressing the CS protein of Plasmodium falciparum contain CTL that specifically kill L cell fibroblasts transfected with the gene encoding the same CS protein. The peptide epitope from the CS protein that is recognized by CTL from this strain of mice is from a variant region of the protein.
- Publication
Nature, 1988, Vol 334, Issue 6179, p258
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/334258a0