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- Title
High oxygen concentrations inhibit Acanthamoeba spp.
- Authors
Sifaoui, Ines; -Yanes, Eulalia Capote; Reyes-Batlle, María; Rodríguez-Expósito, Rubén L.; Bazzocchi, Isabel L.; Jiménez, Ignacio A.; Piñero, José E.; Lorenzo-Morales, Jacob; Weaver, Lindell K.
- Abstract
Efficacious treatments against Acanthamoeba Keratitis (AK) is challenging, often ineffective and linked to the intragenotype variation in the drug efficacy. Increased oxygen can facilitate host response and can inhibit some organisms. Herein, we report the effect of increased oxygen concentrations on Acanthamoeba spp. growth and its effect on ROS (reactive oxygen species) production. The exposition to pure oxygen could reduce cell growth by at least 60% for Acanthamoeba castellanii Neff, Acanthamoeba polyphaga, and Acanthamoeba griffini. The increase in ROS production confirming that oxygen cell's growth inhibition was due to oxidative stress. Further studies are needed to determine oxygen saturation level, time of oxygen exposition, and number of sessions needed to eliminate the parasite.
- Subjects
ACANTHAMOEBA; OXYGEN saturation; REACTIVE oxygen species; ACANTHAMOEBA castellanii; ACANTHAMOEBA keratitis
- Publication
Parasitology Research, 2021, Vol 120, Issue 8, p3001
- ISSN
0932-0113
- Publication type
Article
- DOI
10.1007/s00436-021-07219-3