We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
In-vitro activities of amphotericin B, itraconazole and voriconazole against 150 clinical and environmental Aspergillus fumigatus isolates.
- Authors
Verweij, PE; Mensink, M; Rijs, AJMM; Donnelly, JP; Meis, JFGM; Denning, DW; Verweij, P E; Rijs, A J; Donnelly, J P; Meis, J F; Denning, D W
- Abstract
The in-vitro activity of amphotericin B, itraconazole and voriconazole against 130 clinical and 20 environmental Aspergillus fumigatus isolates was tested with an agar dilution method using RPMI 1640 medium. Itraconazole-susceptible (AF71) and -resistant (AF90) isolates were included in each test and all isolates were tested in duplicate. Geometric mean MIC values (ranges) at 48 h and 72 h were, respectively, amphotericin B, 0.91 (0.25-2) and 1.50 (1-4) mg/L; itraconazole, 0.25 (0.06-1) and 0.48 (0.125-8) mg/L; and voriconazole, 0.56 (0.25-8) and 0.78 (0.25-8) mg/L. The reproducibility of the results was high for all drugs. In-vitro resistance of A. fumigatus to the tested antifungal agents was uncommon and the MICs of itraconazote were half those of voriconazole (P < 0.01).
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1998, Vol 42, Issue 3, p389
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/42.3.389