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- Title
Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model.
- Authors
Shapiro, MA; Sesnie, JC; Desaty, TM; Griffin, TJ; Heifetz, CL; Shapiro, M A; Sesnie, J C; Desaty, T M; Griffin, T J; Heifetz, C L
- Abstract
A deep-seated Pseudomonas aeruginosa mouse kidney abscess model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, with that of clinically relevant standard drugs. Following 50 mg/kg oral doses, twice daily for five consecutive days, clinafloxacin produced a 4 log decrease in mean bacterial count, the greatest decrease of all drugs tested. The same dosage regimen resulted in complete bacterial eradication in 88% of the kidneys. No other compound produced total bacterial clearance in 50% of the kidneys at the highest dose tested.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1998, Vol 41, Issue 3, p403
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/41.3.403