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- Title
Evolution of resistance to metronidazole and clarithromycin in Helicobacter pylori clinical isolates from Spain.
- Authors
López-Brea, M; Domingo, D; Sanchez, I; Alarcon, T; López-Brea, M
- Abstract
The aim of this study was to determine the frequency of resistance to amoxycillin, tetracycline, metronidazole and clarithromycin in 282 Helicobacter pylori clinical isolates from Spain and to evaluate the evolution of resistance over the five years of this study. The overall percentage of resistance was 19.9% for metronidazole and 3.5% for clarithromycin. Resistance to metronidazole rose from 9% in 1991 to 21.6% in 1995, although 33.3% resistance was found in 1993. Clarithromycin resistance was not detected in 1991 or 1992 and the rate was 4%, 3.4% and 4.4% in 1993, 1994 and 1995, respectively. No amoxycillin or tetracycline resistance was found.
- Subjects
SPAIN; AMOXICILLIN; ANTIBIOTICS; COMPARATIVE studies; DRUG resistance in microorganisms; HELICOBACTER pylori; METRONIDAZOLE; RESEARCH methodology; MEDICAL cooperation; RESEARCH; TETRACYCLINE; EVALUATION research; ANTIPROTOZOAL agents; CLARITHROMYCIN; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1997, Vol 40, Issue 2, p279
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/40.2.279